Fast simulation of the CEPC detector with Delphes

Fast simulation tools are highly appreciated in particle physics phenomenology studies, especially in the exploration of the physics potential of future experimental facilities. The Circular Electron Positron Collider is a proposed Higgs and Z factory that can precisely measure the Higgs boson properties and the electroweak precision observables. A fast-simulation toolkit dedicated to the CEPC detector has been developed using Delphes. The comparison shows that this fast simulation tool is highly consistent with the full simulation, on a set of benchmark distributions. Therefore, we recommend this fast simulation toolkit for CEPC phenomenological investigations

Filament L1482 in the California molecular cloud

Aims. The process of gravitational fragmentation in the L1482 molecular filament of the California molecular cloud is studied by combining several complementary observations and physical estimates. We investigate the kinematic and dynamical states of this molecular filament and physical properties of several dozens of dense molecular clumps embedded therein. Methods. We present and compare molecular line emission observations of the J=2--1 and J=3--2 transitions of 12CO in this molecular complex, using the KOSMA 3-meter telescope. These observations are complemented with archival data observations and analyses of the 13CO J=1--0 emission obtained at the Purple Mountain Observatory 13.7-meter radio telescope at Delingha Station in QingHai Province of west China, as well as infrared emission maps from the Herschel Space Telescope online archive, obtained with the SPIRE and PACS cameras. Comparison of these complementary datasets allow for a comprehensive multi-wavelength analysis of the L1482 molecular filament. Results. We have identified 23 clumps along the molecular filament L1482 in the California molecular cloud. All these molecular clumps show supersonic non-thermal gas motions. While surprisingly similar in mass and size to the much better known Orion molecular cloud, the formation rate of high-mass stars appears to be suppressed in the California molecular cloud relative to that in the Orion molecular cloud based on the mass-radius threshold derived from the static Bonnor Ebert sphere. Our analysis suggests that these molecular filaments are thermally supercritical and molecular clumps may form by gravitational fragmentation along the filament. Instead of being static, these molecular clumps are most likely in processes of dynamic evolution.Comment: 10 pages, 9 figures, 2 tables, accepted to Astronomy and Astrophysic

Metabonomic Profiles Delineate the Effect of Traditional Chinese Medicine Sini Decoction on Myocardial Infarction in Rats

Background: In spite of great advances in target-oriented Western medicine for treating myocardial infarction (MI), it is still a leading cause of death in a worldwide epidemic. In contrast to Western medicine, Traditional Chinese medicine (TCM) uses a holistic and synergistic approach to restore the balance of Yin-Yang of body energy so the body’s normal function can be restored. Sini decoction (SND) is a well-known formula of TCM which has been used to treat MI for many years. However, its holistic activity evaluation and mechanistic understanding are still lacking due to its complex components. Methodology/Principal Findings: A urinary metabonomic method based on nuclear magnetic resonance and ultra highperformance liquid chromatography coupled to mass spectrometry was developed to characterize MI-related metabolic profiles and delineate the effect of SND on MI. With Elastic Net for classification and selection of biomarkers, nineteen potential biomarkers in rat urine were screened out, primarily related to myocardial energy metabolism, including the glycolysis, citrate cycle, amino acid metabolism, purine metabolism and pyrimidine metabolism. With the altered metabolism pathways as possible drug targets, we systematically analyze the therapeutic effect of SND, which demonstrated that SND administration could provide satisfactory effect on MI through partially regulating the perturbed myocardial energy metabolism. Conclusions/Significance: Our results showed that metabonomic approach offers a useful tool to identify MI-relate

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes.

Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults. Nevertheless, the underlying mechanisms governing this hepatoprotection remain obscure. In the present study, we hypothesized that macrophages and their M1/M2 activation critically involve in the hepatoprotection conferred by liver fibrosis. Our findings demonstrated that liver fibrosis manifested a beneficial role for host survival and apoptosis resistance. Hepatoprotection in the fibrotic liver was tightly related to innate immune tolerance. Macrophages undertook crucial but divergent roles in homeostasis and fibrosis: depleting macrophages in control mice protected from acute insult; conversely, depleting macrophages in fibrotic liver weakened the hepatoprotection and gave rise to exacerbated liver injury upon insult. The contradictory effects of macrophages can be ascribed, to a great extent, to the heterogeneity in macrophage activation. Macrophages in fibrotic mice exhibited M2-preponderant activation, which was not the case in acutely injured liver. Adoptive transfer of M2-like macrophages conferred control mice conspicuous protection against insult. In vitro, M2-polarized macrophages protected hepatocytes against apoptosis. Together, M2-like macrophages in fibrotic liver exert the protective effects against lethal insults through conferring apoptosis resistance to hepatocytes